Job Description

The Manager – PilotPlnt/Clin Mfg is a mid-level manager position responsible for on floor leadership and functional management for all areas of operation within the Chesterfield Manufacturing Facility, which manufactures DNA plasmids derived from microbial culture processes for use in clinical trials in support of Pfizer’s mRNA vaccine and gene therapy pipelines. In addition, the facility also performs scale-up work for other modalities such as polysaccharide vaccines. This position leads a group of technicians and scientists to support CMF operations and works closely with other members of the CMF management team to ensure timely delivery of supply and process scale-up commitments.

This position is responsible for identifying operational efficiency improvements and planning and implementing those improvements within the operational area. Must be capable of implementing change to the manufacturing infrastructure to ensure area operational success. Responsible for coaching and developing staff, identifying growth opportunities and mentoring so that all staff can realize their full potentials. This position will provide support to the Director, CMF on strategic initiatives for Technology and Innovation.

ROLE RESPONSIBILITIES

Accountable for operational deliverables across CMF Operations.

Works across areas to integrate manufacturing activities to meet demanding development timelines and objectives and works with other area leaders to ensure that high quality, timely, and achievable project objectives are established and communicated.

Provides a mature and experienced operations perspective for multiple unit operations supporting pre-clinical manufacturing and process scale up approaches.

Broad general knowledge of all unit operations performed in the manufacturing facility and has the ability to guide junior colleagues to make correct decisions during the course of daily operations.

With the Director, defines the organizational and resource requirements for the specific area of operation utilizing a flexible SME assignment/staffing strategy to enable efficient project resourcing.

Ensures an optimal balance of experienced technical staff for innovation and flexibility to drive projects.

Sets departmental standards that encourage self-motivation and flawless execution with the goal of continuous improvement.

Responsible for planning and developing staff, identifying growth opportunities and mentoring so that all staff can realize their full potential, as well as dealing with performance issues appropriately.

Manages the administrative responsibilities of the manufacturing operations within the manufacturing organization for seamless integration across other functions within BRD.

BASIC QUALIFICATIONS

B.S./M.S. in Chemical/Biochemical Engineering, or Cell Biology, Biochemistry, Microbiology and 5+ years of industry experience, preferably in GMP manufacturing.

In depth technical and bioprocess unit operation expertise, direct or matrix management and project management training/experience.

Demonstrated supervision/leadership of operations staff, including key participation on multi-disciplinary manufacturing teams.

Extensive theoretical and practical knowledge in a wide variety of heterologous expression systems with a focus on E. coli cells.

Experience developing and executing relevant recovery and purification processes derived from microbial and/or mammalian production cultures.

PREFERRED QUALIFICATIONS

Experience in supporting the scale-up and tech transfer from development laboratory to GMP manufacturing.

Extensive knowledge of GMP and Biotechnology CMC regulatory requirements.

Excellent oral and written communication skills, and the ability to mentor junior staff and peers.




PHYSICAL/MENTAL REQUIREMENTS

Must be able to lift 40 lbs and stand for long periods of time.


Relocation support available

Work Location Assignment: On Premise

Other Job Details
Relocation assistance may be available based on business needs and/or eligibility.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.